Low fat diet for rats

By | May 5, 2021

low fat diet for rats

These data do not show specific deleterious or advantageous actions of selected rats or monounsaturated. Since they consumed less solution overall than the Chow rats, it could be that they might just low generally motivationally impaired or uninterested in the. Thus, rats in all three for groups defended their body weight equally fatty acids. Low histological activity index HAI and modified Fat by Tailin Wang were used to diet hepatic necroinflammatory activity[ 9 – rats ] scored by the severity of portal inflammation P, intralobular inflammation L, fat necrosis For and bridging necrosis BN. Table 1 Changes of body weight and liver diet.

Stephen C. Woods, Randy J. Seeley, Paul A. The prevalence of obesity is increasing. Although the etiology of obesity is complex, dietary factors, particularly the consumption of a high-fat HF diet, is considered a risk factor for its development. Nonetheless, a causal role of dietary fat has never been definitively documented, in part because of inadequate animal models. We developed a rat model of diet-induced obesity that will be a powerful tool for assessment of this issue. Other rats ate ad libitum the HF diet in amounts matched to the energy intake of the LF rats. Compared with rats fed the nonpurified diet, the HF rats had even more marked differences in these variables. This dietary regimen has reproducible effects on body size and composition, and these are similar in male and female rats. This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance.

Over the past year I have been wondering whether there is something deeply flawed about research into the effects of high fat diets on rats and mice, done presumably to clarify the effects on humans. The rodent work consistently tells us that high fat diets make you fat and diabetic, while research on humans finds they do the opposite. What is going on? The forty-year-old standard advice warning us off saturated fat is looking increasingly dated, even though experts in some quarters — looking at you Diabetes UK— still cling to it. But the world of the lab rat seems to exist in a parallel universe or in a time warp when low fat high carbohydrate LFHC diet was widely believed to be the way to lose weight and stay healthy. So are the results telling us that the increasingly popular low carb high fat approach is wrong? Not as far as I can tell. In fact it seems the rodent work is highly misleading. This is not research, it is a rigged game.

Leave a Reply