The consumption of seed oils high in the omega-6 polyunsaturated fat PUFA linoleic acid LA contributes to low-grade inflammation, oxidative stress, endothelial dysfunction and atherosclerosis. This may explain why increasing LA intake can actually lower AA levels due to an increased breakdown into harmful proinflammatory metabolites. Additionally, there is an AA-independent pathway of inflammation promoted by the intake of omega-6 seed oils such as increased production of oxidised linoleic acid metabolites OXLAMs and proinflammatory LA CYP-eicosanoids. Indeed, compared with high-oleic sunflower oil 3. The recent announcement of results from the Reduction of Cardiovascular Events with EPA Intervention Trial REDUCE-IT study, which found a highly significant reduction in cardiovascular events using Vascepa 4 g per day, suggests how these anti-inflammatory benefits may cause reductions in clinical endpoints. The authors suggested that fish oil in patients with PAD would likely improve inflammation, symptoms and possibly reduce the progression and severity of the disease. However, LA in red blood cells and in plasma does not correlate well with intake, whereas DHA, especially in red blood cells but also in plasma, had good correlation EPA also had fairly good correlation with intake as well but only with red blood cell levels. The reddening and swelling of areas in the body generally occurs because of the release of omega-6 AA eicosanoids and cytokines. Aspirin, for example, a well-known pain reliever and fever reducer, inhibits COX1 from breaking down AA, thereby preventing the inflammatory response. Omega-3s PUFAs act to prevent chronic low-grade inflammation.
The most popular are omega-3 well oil, but there are also plant-based DHA and EPA supplements extracted from algae. Consider collagen powder supplement as fatty acids derived from fish.
Excess Omega-6 is just one of the reasons behind chronic, low-level inflammation. Other reasons include excess blood glucose, poor probiotic status, obesity, lack of sleep, gluten consumption, gut dydbiosis, etc. Omega-3s and 6s have opposing functions in the body. Think ying-yang. How much Omega-3 or fish oil you need depends on how much Omega-6 you get in your diet. Omega-6 are largely pro-inflammatory. For eons, our ancestors ate a roughly 1 to 1 ratio of these two fats. This is ideal. Part of our myopic love for Omegarich vegetable oils is that it reduces cholesterol. In , the Los Angeles Veterans Trial studied the replacement of dietary saturated fats with Omegarich fats. The group on the high Omega-6 diet had lower cholesterol and fewer cardiovascular events. But they started dying at alarming rates.
Dietary intake of just the right amount of omega-6 and omega-3 fatty acids is crucial for optimal health. Learn more about these fats and strategies to better counsel patients. Of all the different types of fatty acids, only two have been declared essential to human health: linoleic acid LA, an omega-6 fat, and alpha-linolenic acid ALA, an omega-3 fat. The balance between these two essential fatty acids is delicate, however, and too much of one and too little of the other can result in deleterious health consequences. The standard American diet tends to skew the ratio of omega-6 to omega-3 in favor of omega-6 fats, which can contribute to a systemic inflammatory process and the increased prevalence of obesity, cardiovascular and nonalcoholic fatty liver diseases, rheumatoid arthritis, inflammatory bowel diseases IBD, and cancer. Omegas As you probably know, fatty acids are classified according to the length of their carbon chain and the double bonds present on the molecule.