Aryl hydrocarbon receptor AHR agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet HFD have been shown to resist obesity and hepatic steatosis. Tissue-specific knockout of Ahr in mature adipocytes via adiponectin-Cre exacerbates obesity while knockout in liver increases steatosis without having significant effects on obesity. Our previous studies demonstrated that treatment of subcutaneous preadipocytes with exogenous or endogenous AHR agonists disrupts maturation into functional adipocytes in vitro. On a regular control diet, knockout and non-knockout mice showed no differences in weight gain, indicating the protective phenotype arises only when animals are challenged by a HFD. Metabolic syndrome, a cluster of conditions i. Adipose tissue is critical for normal metabolism and its dysfunction plays an essential role in the development of metabolic syndrome [ 4 — 6 ]. Adipose tissue is necessary for regulation of inflammation as well as secretion of adipokines such as adiponectin and leptin [ 7 ]. Adipose tissue is much more diverse than previously appreciated and brown, white, and beige adipose tissues play distinct roles in energy homeostasis. White adipose tissue WAT is found in different anatomical depots e.
Thank you for visiting nature. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. Bronchoalveolar lavage BAL was performed. Lipid levels and lipid peroxidation in lung tissue were measured along with gene expression of multiple cytokines. HFD did not affect respiratory resistance at baseline, but significantly augmented airway responses to methacholine compared to chow diet HFD induced a 3. There was no change in BAL and no change in any other cytokines, lipid levels or lipid peroxidation. Asthma is one of the most common diseases and the prevalence of asthma continues to increase, which has been attributed to the epidemics of obesity 1, 2, 3. Asthma in obesity appears to be different from typical TH2 driven allergic asthma demonstrating a poor response to inhaled corticosteroids 4. Possible mechanisms include breathing at lower lung volumes, altered airway structure, increased airway oxidative stress, and greater systemic inflammation 5. HFD is pro-inflammatory due to direct effects of free fatty acids 7.
D2 used for these studies reached your article limit. Recommendations Abstract Comments You have metabolic pathologies. JAMAMetab Syndr Relat Disord.