Sympathoadrenal hormone concentrations remained unaltered. Addison patients have an increased risk of developing hypoglycemia, probably as a result of increased glucose oxidation and decreased glucose production due to greatly diminished cortisol release, thus leading to improved insulin sensitivity 4. In adrenalectomized rats, free-choice ingestion of sucrose has been shown to reduce the detrimental metabolic effects of cortisol deficiency 5, 6. In some people, comfort food ingestion is likewise favored in stressful situations, increases well-being, and reduces anxiety 8, 9. These changes probably involve the endogenous opioid system 9, Autoimmunity was the underlying cause of the disease in eight of the patients and bilateral adrenalectomy because of pheochromocytoma and venous thrombosis, respectively, in two patients. Adrenal insufficiency was accompanied by hypothyroidism treated by T 4 substitution in nine patients and by chronic atrophic gastritis in three patients. Patients and control subjects except for two men in need of antihypertensive medication and one woman with hypothyroidism treated with T 4 substitution had no other acute or chronic diseases, no further kind of medication, and no abuse of nicotine, alcohol, or drugs. Each volunteer gave written informed consent before participation, and the study was approved by the local ethics committee. Each subject participated in two experimental sessions separated by at least 4 wk. In one condition, subjects had free access to a high-calorie buffet comfort food, consisting of potato chips, peanuts, chocolate, muffins, wine gums, custard, bread rolls, brown bread, cheese, smoked salmon, meat salad, cream cheese, butter, chocolaty hazelnut spread, meatballs, lemonade, drinking chocolate, orange juice, condensed milk, sugar, fruit tea, coffee decaffeinated, and water amounting to a total of offered kilocalories.
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