It appears that concerns about the risk of birth defects from use of Topamax topiramate during pregnancy may impact a new proposed diet drug that combines the epilepsy medication with phentermine. According to an analysis by Vivus Inc. The federal regulatory agency asked Vivus, Inc. Vivus examined data from 15, medical claims involving Topamax and generic topiramate, which is prescribed for treatment of epilepsy and migrains. The analysis found that 0. In March , the FDA required new warnings about the risk of birth defects with Topamax and generic topiramate when the medication is used during the first trimester of pregnancy, a time when many women do not even know that they are pregnant. The FDA urged doctors to avoid giving Topamax to pregnant women or women who are of child-bearing age and at a high risk of pregnancy, as the agency determined that alternative epilepsy and migraine medications were available that may not carry the same risk. Cleft palate and cleft lip occur when parts of the lip or palate fail to completely fuse together. The defect results in the child being born with defects as small as a notched lip to extreme as an open groove that goes from the roof of the mouth to the nose. Cleft palate and cleft lip can cause problems eating and talking and can increase the risk of ear infections, resulting in the need for corrective surgery.
Table 1 Factors associated with not taking folic acid during the first 3 months of pregnancy. It appears that concerns about the risk of birth defects from use of Topamax topiramate during pregnancy may impact a new proposed diet drug that combines the epilepsy medication with phentermine. Prevalence of non-consumption of folic acid Over one-third of women Dublin: Food Safety Authority of Ireland; Why are you offering the medicine at this time? National Center for Biotechnology Information, U. The researchers mailed two questionnaires to each of the mothers participating in the study.
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